Metabolic Health & Body Composition
GLP-1 Agonists (semaglutide / tirzepatide class)
Established metabolic research
FDA-approved peptides with the strongest evidence base on this menu — used to support metabolic health, weight management, and cardiovascular wellness.
Overview
Semaglutide and tirzepatide are FDA-approved GLP-1 (and, for tirzepatide, GLP-1 / GIP) receptor agonists with the strongest clinical evidence base of any compound on this menu. Landmark trials include STEP 1 (semaglutide: mean weight change −14.9% vs −2.4% placebo at 68 weeks), SURMOUNT-1 (tirzepatide 15 mg: up to 22.5% weight reduction at 72 weeks), and the SELECT cardiovascular outcomes trial (semaglutide reduced major adverse cardiovascular events by 20%). Compounded versions exist in a separate, more constrained regulatory category since 2025.
Evidence: established human research
In consultation, clients often ask
The difference between branded FDA-approved product and compounded options.
How we structure baseline labs, follow-up, and the off-ramp conversation.
Regulatory & sourcing
Semaglutide (Wegovy/Ozempic) and tirzepatide (Zepbound/Mounjaro) are FDA-approved. Tirzepatide shortage resolved December 19, 2024; semaglutide shortage resolved February 21, 2025. On April 30, 2026, the FDA proposed to permanently exclude semaglutide, tirzepatide, and liraglutide from the 503B bulks list — closing the large-scale outsourcing-facility compounding pathway. Patient-specific 503A compounding remains possible only with documented individual clinical need.
References
Wilding JPH, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1). N Engl J Med. 2021;384:989–1002.
Jastreboff AM, et al. Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1). N Engl J Med. 2022;387:205–216.
Lincoff AM, et al. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT). N Engl J Med. 2023;389:2221–2232.
Please read
Peptide therapy at Jaed Aesthetics is offered as a private wellness consultation service. None of the peptides discussed on this menu are FDA-approved for the wellness areas described, and some are investigational or available only through compounding pharmacies operating under FDA Sections 503A or 503B. Several peptides on this menu have primarily pre-clinical or animal evidence and limited published human data; we note this honestly under each entry. Any decision to proceed, the specific peptide selected, route of administration, dosing, monitoring, and pricing are determined one-on-one with our nurse practitioner during consultation. Nothing on this page constitutes medical advice, a diagnosis, or a treatment recommendation.
By consultation
Schedule a peptide consultation, in the basin.
Pricing, availability, and treatment plans are determined one-on-one. Bring your goals — we'll work the plan from there.