Immune Response & Gut Health
LL-37
Studied in host-defense research
The body's own host-defense peptide — used to support immune function, antimicrobial activity, and skin / wound-environment health.
Overview
LL-37 is the only cathelicidin produced by the human body, a host-defense peptide present in skin, mucosal surfaces, and immune cells. It is studied in the context of innate immunity, antimicrobial activity, and wound-environment research. Published human use is largely topical and investigational; injectable wellness use is not supported by completed clinical trials.
Evidence: primarily pre-clinical / limited human data
In consultation, clients often ask
What's actually known about LL-37 vs. what's marketed.
Whether topical or systemic approaches make sense for my situation.
Regulatory & sourcing
Not FDA-approved. Not on the 503A bulks list. Pre-clinical literature notes that LL-37 has both pro- and anti-inflammatory effects and has been implicated in certain autoimmune pathologies (e.g., systemic lupus erythematosus) — relevant for screening.
References
Duplantier AJ, van Hoek ML. The Human Cathelicidin Antimicrobial Peptide LL-37 as a Potential Treatment for Polymicrobial Infected Wounds. Front Immunol. 2013;4:143.
Tomasinsig L, et al. Antimicrobial Peptides of the Cathelicidin Family: Focus on LL-37 and Its Modifications. Int J Mol Sci. 2025;26(16):8103.
Please read
Peptide therapy at Jaed Aesthetics is offered as a private wellness consultation service. None of the peptides discussed on this menu are FDA-approved for the wellness areas described, and some are investigational or available only through compounding pharmacies operating under FDA Sections 503A or 503B. Several peptides on this menu have primarily pre-clinical or animal evidence and limited published human data; we note this honestly under each entry. Any decision to proceed, the specific peptide selected, route of administration, dosing, monitoring, and pricing are determined one-on-one with our nurse practitioner during consultation. Nothing on this page constitutes medical advice, a diagnosis, or a treatment recommendation.
By consultation
Schedule a peptide consultation, in the basin.
Pricing, availability, and treatment plans are determined one-on-one. Bring your goals — we'll work the plan from there.