Cognitive Health & Mood
PE-22-28
Explored in neurorecovery research
An exploratory peptide studied in mood and stroke recovery — currently the most cautiously framed conversation on the menu, with no completed human trials.
Overview
PE-22-28 is a synthetic 7-amino-acid spadin analog studied as a TREK-1 potassium-channel inhibitor in pre-clinical antidepressant and stroke-recovery models. The entire evidence base is rodent and in vitro; no human clinical trials have been completed.
Evidence: primarily pre-clinical / limited human data
In consultation, clients often ask
The fact that no human trials exist and what that means for expectations.
Why this is one of the most cautiously framed conversations on the menu.
Regulatory & sourcing
Not FDA-approved. Not on the 503A bulks list. No completed human safety or efficacy trials. Discussed only in a clearly investigational framing.
References
Djillani A, et al. Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity. Frontiers in Pharmacology. 2017; PMID 28955242.
Pietri M, et al. PE 22-28 and stroke recovery in rodent models. Neuropharmacology. 2019; PMID 31325429.
Please read
Peptide therapy at Jaed Aesthetics is offered as a private wellness consultation service. None of the peptides discussed on this menu are FDA-approved for the wellness areas described, and some are investigational or available only through compounding pharmacies operating under FDA Sections 503A or 503B. Several peptides on this menu have primarily pre-clinical or animal evidence and limited published human data; we note this honestly under each entry. Any decision to proceed, the specific peptide selected, route of administration, dosing, monitoring, and pricing are determined one-on-one with our nurse practitioner during consultation. Nothing on this page constitutes medical advice, a diagnosis, or a treatment recommendation.
By consultation
Schedule a peptide consultation, in the basin.
Pricing, availability, and treatment plans are determined one-on-one. Bring your goals — we'll work the plan from there.