Sexual Health & Hormones
PT-141 (Bremelanotide)
Studied in intimacy and desire
An FDA-approved peptide that works on the brain's desire pathways — used to support intimacy and sexual wellness in women, and off-label in men.
Overview
PT-141 is a melanocortin-receptor agonist that acts centrally on pathways associated with sexual desire and arousal rather than peripherally on blood flow. It is FDA-approved under the brand name Vyleesi (June 2019) for hypoactive sexual desire disorder (HSDD) in premenopausal women, based on the Phase 3 RECONNECT trials. Off-label discussion in men and in other contexts is appropriately framed during consultation.
Evidence: established human research
In consultation, clients often ask
The difference between PT-141's central mechanism and PDE5 inhibitors.
Side-effect profile, particularly nausea (reported by ~40% on first dose) and transient blood-pressure changes.
Regulatory & sourcing
FDA-approved (Vyleesi) for HSDD in premenopausal women — the only on-label indication. Use outside that indication is off-label and is determined with the nurse practitioner. Compounded intranasal formulations exist in a separate regulatory category.
References
Kingsberg SA, et al. Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials (RECONNECT). Obstetrics & Gynecology.
FDA Vyleesi (bremelanotide) prescribing information.
Please read
Peptide therapy at Jaed Aesthetics is offered as a private wellness consultation service. None of the peptides discussed on this menu are FDA-approved for the wellness areas described, and some are investigational or available only through compounding pharmacies operating under FDA Sections 503A or 503B. Several peptides on this menu have primarily pre-clinical or animal evidence and limited published human data; we note this honestly under each entry. Any decision to proceed, the specific peptide selected, route of administration, dosing, monitoring, and pricing are determined one-on-one with our nurse practitioner during consultation. Nothing on this page constitutes medical advice, a diagnosis, or a treatment recommendation.
By consultation
Schedule a peptide consultation, in the basin.
Pricing, availability, and treatment plans are determined one-on-one. Bring your goals — we'll work the plan from there.