Recovery & Repair
TB-500 (Thymosin Beta-4 fragment)
Explored for repair and recovery
Used to support tissue repair, post-exertion recovery, and the body's natural restoration response — often discussed alongside BPC-157 for athletic recovery.
Overview
TB-500 is a synthetic fragment of thymosin beta-4, a naturally occurring actin-binding peptide involved in cell migration and tissue repair. It is discussed in the context of recovery, soft-tissue support, and post-exertion restoration. Most supporting data is animal or in vitro; completed Phase 2 or 3 human trials for tendon, ligament, or muscle indications do not yet exist.
Evidence: primarily pre-clinical / limited human data
In consultation, clients often ask
How does TB-500 differ from full-length pharmaceutical thymosin beta-4 that's been in eye-drop trials.
What the evidence base honestly looks like for the use case I'm asking about.
Regulatory & sourcing
Not FDA-approved. Previously Category 2; nomination withdrawn in April 2026, currently in a regulatory gray zone awaiting PCAC review. Banned by WADA. Discussed with the nurse practitioner.
References
Sosne G, et al. Thymosin beta-4: Phase 2 randomized study in patients with severe dry eye disease. Annals of the New York Academy of Sciences.
Goldstein AL, Hannappel E, Sosne G, Kleinman HK. Thymosin β4: a multi-functional regenerative peptide. Expert Opin Biol Ther.
Please read
Peptide therapy at Jaed Aesthetics is offered as a private wellness consultation service. None of the peptides discussed on this menu are FDA-approved for the wellness areas described, and some are investigational or available only through compounding pharmacies operating under FDA Sections 503A or 503B. Several peptides on this menu have primarily pre-clinical or animal evidence and limited published human data; we note this honestly under each entry. Any decision to proceed, the specific peptide selected, route of administration, dosing, monitoring, and pricing are determined one-on-one with our nurse practitioner during consultation. Nothing on this page constitutes medical advice, a diagnosis, or a treatment recommendation.
By consultation
Schedule a peptide consultation, in the basin.
Pricing, availability, and treatment plans are determined one-on-one. Bring your goals — we'll work the plan from there.